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Nat Commun. 2016 Jan 26;7:10410. doi: 10.1038/ncomms10410.

Intestinal microbiome is related to lifetime antibiotic use in Finnish pre-school children.

Author information

1
Immunobiology Research Program, Department of Bacteriology and Immunology, University of Helsinki, Haartmaninkatu 3, PO Box 21, 00014 Helsinki, Finland.
2
Research Department, Social Insurance Institution, Turku, Peltolantie 3, 20720, Finland.
3
Valio Limited, R&D, Meijeritie 4, 00370 Helsinki, Finland.
4
European Molecular Biology Laboratory, PO Box 1022.40, 69012 Heidelberg, Germany.
5
Department of Veterinary Biosciences, University of Helsinki, PO Box 66, 00014 Helsinki, Finland.
6
Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB Wageningen, The Netherlands.

Abstract

Early-life antibiotic use is associated with increased risk for metabolic and immunological diseases, and mouse studies indicate a causal role of the disrupted microbiome. However, little is known about the impacts of antibiotics on the developing microbiome of children. Here we use phylogenetics, metagenomics and individual antibiotic purchase records to show that macrolide use in 2-7 year-old Finnish children (N=142; sampled at two time points) is associated with a long-lasting shift in microbiota composition and metabolism. The shift includes depletion of Actinobacteria, increase in Bacteroidetes and Proteobacteria, decrease in bile-salt hydrolase and increase in macrolide resistance. Furthermore, macrolide use in early life is associated with increased risk of asthma and predisposes to antibiotic-associated weight gain. Overweight and asthmatic children have distinct microbiota compositions. Penicillins leave a weaker mark on the microbiota than macrolides. Our results support the idea that, without compromising clinical practice, the impact on the intestinal microbiota should be considered when prescribing antibiotics.

PMID:
26811868
PMCID:
PMC4737757
DOI:
10.1038/ncomms10410
[Indexed for MEDLINE]
Free PMC Article

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