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Iran J Parasitol. 2015 Oct-Dec;10(4):625-31.

Efficacy of the Bunium persicum (Boiss) Essential Oil against Acute Toxoplasmosis in Mice Model.

Author information

1
Dept. of Medical Parasitology and Mycology, Kerman University of Medical Sciences, Kerman, Iran.
2
Research Center for Tropical and Infectious Diseases, Kerman University of Medical Science, Kerman, Iran.
3
Department of Physiology, Kerman University of Medical Sciences, Kerman, Iran.

Abstract

BACKGROUND:

We evaluated the in vivo activity of Bunium persicum (Boiss) essential oil on infected mice with acute toxoplasmosis.

METHODS:

To evaluate prophylactic effects, male NMRI mice received B. persicum essential oil at the concentrations of 0.05 and 0.1 mL/kg for 14 days. After 24 h mice were infected intraperitonealy with 1×10(4) tachyzoites of T. gondii, RH strain. In order to investigate therapeutic effects, mice were infected and then received B. persicum oil at the concentrations of 0.05 and 0.1 ml/kg two times a day for 5 days. The time/mean time of death in all infected mice and the number of tachyzoites from infected mice were recorded.

RESULTS:

The time/mean time of death of infected mice was 8 and 9 days after oral administration of B. persicum oil at the concentration of 0.05 and 0.1 mL/kg, respectively (P<0.05). In contrast, the time/mean time of death control group was 5 days. In addition, B. persicum significantly reduced the mean number of tachyzoites compared with control group. The time/mean time of death of infected mice was 6 and 7 days after oral administration of B. persicum essential oil at the concentration of 0.05 and 0.1 mL/kg, respectively. In contrast, the time/mean time of death control group was 5 days. B. persicum especially at the concentration of 0.1 ml/kg significantly reduced the mean number of tachyzoites compared with control group.

CONCLUSION:

The results showed the potential of B. persicum essential oil as a natural source for the production of new prophylactic agent for use in toxoplasmosis.

KEYWORDS:

Bunium persicum Boiss; Prophylactic; Therapeutic; Toxoplasma gondii

PMID:
26811730
PMCID:
PMC4724840

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