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Lupus. 2016 May;25(6):563-72. doi: 10.1177/0961203316629001. Epub 2016 Jan 24.

Eppur Si Muove: vitamin D is essential in preventing and modulating SLE.

Author information

1
The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
2
The Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel Incumbent of the Laura Schwarz-Kip Chair for Research of Autoimmune Diseases, Tel-Aviv University, Israel shoenfel@post.tau.ac.il.

Abstract

Systemic lupus erythematosus (abbreviated SLE or lupus) is a systemic autoimmune disease, with genetic, immunologic, hormonal, and environmental factors.(1)One of the environmental factors that has been studied over the years is vitamin D, which is created in the human body in response to exposure to sunlight and ultraviolet (UV) radiation.This review aims at examining findings from recent years, specifically 2013-2014, regarding the relationship between vitamin D deficiency and SLE flares, severity, and clinical manifestation, as well as to examine the treatment options derived from this relationship.

KEYWORDS:

APS; SLE; UV light; Vitamin D; estrogens; tolerance

PMID:
26811372
DOI:
10.1177/0961203316629001
[Indexed for MEDLINE]

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