An Overview of Genome-Wide Association Studies in Alzheimer's Disease

Luxi Shen; Jianping Jia

doi:10.1007/s12264-016-0011-3

An Overview of Genome-Wide Association Studies in Alzheimer's Disease

Neurosci Bull. 2016 Apr;32(2):183-90. doi: 10.1007/s12264-016-0011-3. Epub 2016 Jan 25.

Authors

Luxi Shen¹, Jianping Jia^{2

3

4

5}

Affiliations

¹ Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing, 100053, China.
² Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing, 100053, China. jjp@ccmu.edu.cn.
³ Center of Alzheimer's Disease, Beijing Institute for Brain Disorders, Beijing, 100053, China. jjp@ccmu.edu.cn.
⁴ Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing, 100053, China. jjp@ccmu.edu.cn.
⁵ Neurodegenerative Laboratory of Ministry of Education of the People's Republic of China, Beijing, 100053, China. jjp@ccmu.edu.cn.

Abstract

Genome-wide association studies (GWASs) have revealed a plethora of putative susceptibility genes for Alzheimer's disease (AD). With the sole exception of the APOE gene, these AD susceptibility genes have not been unequivocally validated in independent studies. No single novel functional risk genetic variant has been identified. In this review, we evaluate recent GWASs of AD, and discuss their significance, limitations, and challenges in the investigation of the genetic spectrum of AD.

Keywords: Alzheimer’s disease susceptibility genes; Apolipoprotein E; Association analysis; Common variant.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Alzheimer Disease / genetics*
Apolipoprotein E4 / genetics
Genetic Predisposition to Disease / genetics*
Genome-Wide Association Study*
Humans
Risk Factors

Substances

Apolipoprotein E4