Format

Send to

Choose Destination
Hum Vaccin Immunother. 2016 Apr 2;12(4):907-15. doi: 10.1080/21645515.2015.1119345. Epub 2016 Jan 25.

Impact of host genetic polymorphisms on vaccine induced antibody response.

Linnik JE1,2,3, Egli A1,4.

Author information

1
a Applied Microbiology Research , Department of Biomedicine, University Basel , Basel , Switzerland.
2
b Department of Biosystems Science and Engineering , ETH Zürich , Basel , Switzerland.
3
c Swiss Institute of Bioinformatics , Basel , Switzerland.
4
d Clinical Microbiology, University Hospital Basel , Basel , Switzerland.

Abstract

Many host- and vaccine-specific factors modulate an antibody response. Host genetic polymorphisms, in particular, modulate the immune response in multiple ways on different scales. This review article describes how information on host genetic polymorphisms and corresponding immune cascades may be used to generate personalized vaccine strategies to optimize the antibody response.

KEYWORDS:

GWAS; Influenza; Measles; SNP; antibodies; genetic polymorphism; immune response; individualized vaccination; systems biology; vaccine

PMID:
26809773
PMCID:
PMC4962936
DOI:
10.1080/21645515.2015.1119345
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center