Format

Send to

Choose Destination
APMIS. 2016 Apr;124(4):291-8. doi: 10.1111/apm.12507. Epub 2016 Jan 25.

KiSS-1 expression in oral squamous cell carcinoma and its prognostic significance.

Author information

1
Department of Oral Pathology, School of Dentistry, Seoul National University, Seoul, Korea.
2
Department of Oral and Maxillofacial Pathology, School of Dentistry, Kyung Hee University, Seoul, Korea.
3
Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.

Abstract

Downregulated expression of KiSS-1 has been correlated with tumor progression, metastasis, and patient prognosis in various human malignancies. However, there is no information regarding the expression of KiSS-1 in oral squamous cell carcinoma (OSCC). Our aims were to examine KiSS-1 expression in OSCC tissue samples and cell lines and to determine its prognostic significance. KiSS-1 expression was significantly lower in lymph node (LN) metastases than in primary tumor tissues. Five of six OSCC cell lines showed absence or relatively low expression of KiSS-1. Correlations between KiSS-1 expression and clinicopathological parameters were statistically assessed. There were significant correlations between KiSS-1 expression and LN metastasis (p = 0.007), TNM stage (p = 0.024), and local recurrence (p = 0.012). In the Kaplan-Meier survival analysis, negative KiSS-1 expression significantly correlated with poorer overall survival (OS) and disease-free survival (DFS) (p = 0.000 and 0.000, respectively). Multivariate analysis using Cox regression modeling revealed that KiSS-1 expression was an independent prognostic factor for both OS and DFS (p = 0.001 and 0.000, respectively). Our findings suggested that KiSS-1 downregulation may play a role in tumor progression and metastasis of OSCC and may be a reliable biomarker for predicting clinical outcome in OSCC.

KEYWORDS:

KiSS-1; metastasis; oral squamous cell carcinoma; prognosis

PMID:
26809635
DOI:
10.1111/apm.12507
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center