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J Agric Food Chem. 2016 Feb 17;64(6):1283-90. doi: 10.1021/acs.jafc.5b05812. Epub 2016 Feb 3.

An Anthocyanin-Rich Extract of Acai (Euterpe precatoria Mart.) Increases Stress Resistance and Retards Aging-Related Markers in Caenorhabditis elegans.

Author information

1
Institute of Pharmacy and Molecular Biotechnology, Heidelberg University , , INF 364, D-69120 Heidelberg, Germany.
2
Department of Food Chemistry and Toxicology, Molecular Nutrition, University of Kaiserslautern , Erwin-Schroedinger-Strasse 52, D-67663 Kaiserslautern, Germany.

Abstract

Acai fruits (Euterpe precatoria) are rich in antioxidant anthocyanins. Acai consumption is believed to have many health benefits; however, relevant detailed scientific investigations are limited. The current study aimed to investigate an anthocyanin-rich extract from E. precatoria fruits (AE) with regard to its antioxidant and antiaging properties using the model organism Caenorhabditis elegans. AE can protect the worms against oxidative stress and can ameliorate accumulation of reactive oxygen species in vivo. The expression of stress-response genes, such as sod-3::GFP, was upregulated while hsp-16::GFP was down-regulated after AE treatment. Studies with DAF-16/FOXO mutants indicated that some of the antioxidant effects are mediated by this transcription factor. AE can modulate the development of age-related markers, such as pharyngeal pumping. Despite the apparent antioxidant activity, no lifespan-prolonging effect was observed.

KEYWORDS:

Caenorhabditis elegans; acai; aging; anthocyanins; antioxidants; oxidative stress

PMID:
26809379
DOI:
10.1021/acs.jafc.5b05812
[Indexed for MEDLINE]

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