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Ann Occup Environ Med. 2016 Jan 22;28:5. doi: 10.1186/s40557-015-0086-8. eCollection 2016.

Evaluation of mercury exposure level, clinical diagnosis and treatment for mercury intoxication.

Author information

1
Department of Occupational & Environmental Medicine, Dong-A University Hospital, 26, Daesingongwon-ro, Seo-gu, Busan, Republic of Korea ; Heavy-Metal Exposure Environmental Health Center, Dong-A University, 32, Daesingongwon-ro, Seo-gu, Busan, Republic of Korea.
2
Department of Preventive Medicine, Collage of Medicine, Dong-A University, 32, Daesingongwon-ro, Seo-gu, Busan, Republic of Korea ; Heavy-Metal Exposure Environmental Health Center, Dong-A University, 32, Daesingongwon-ro, Seo-gu, Busan, Republic of Korea.
3
Department of Occupational & Environmental Medicine, Collage of Medicine, Young-Nam University, 170, Hyeonchung-ro, Nam-gu, Daegu, Republic of Korea.
4
Department of Occupational & Environmental Medicine & Institute of Environmental and Occupational Medicine, Pusan Paik Hospital, InJe University, 75, Bokji-ro, Busanjin-gu, Busan, Republic of Korea.
5
Department of Occupational & Environmental Medicine, Inha University Hospital, 27, Inhang-Ro, Jung-Gu, Incheon, Republic of Korea.
6
Department of Occupational and Environmental Medicine, College of Medicine, The Catholic University, 222, Banpo-Daero, Seocho-gu, Seoul, Republic of Korea.
7
Department of Occupational and Environmental Medicine, KS Hospital, 220, Wangbeodeul-ro, Gwangsan-gu, Gwangju, Republic of Korea.
8
Department of Occupational & Environmental Medicine, Gachon University Gil Medical Center, 21, Namdong-daero 774beon-gil, Namdong-gu, Incheon, Republic of Korea.
9
Department of Preventive Medicine, College of Medicine, Dankook University, 119, Dandae-ro, Dongnam-gu, Cheonan-si, Chungcheongnam-do, Republic of Korea.

Abstract

Mercury occurs in various chemical forms, and it is different to health effects according to chemical forms. In consideration of the point, the evaluation of the mercury exposure to human distinguished from occupational and environmental exposure. With strict to manage occupational exposure in factory, it is declined mercury intoxication cases by metallic and inorganic mercury inhalation to occupational exposure. It is increasing to importance in environmental exposure and public health. The focus on the health impact of exposure to mercury is more on chronic, low or moderate grade exposure-albeit a topic of great controversy-, not high concentration exposure by methylmercury, which caused Minamata disease. Recently, the issue of mercury toxicity according to the mercury exposure level, health effects as well as the determination of what mercury levels affect health are in the spotlight and under active discussion. Evaluating the health effects and Biomarker of mercury exposure and establishing diagnosis and treatment standards are very difficult. It can implement that evaluating mercury exposure level for diagnosis by a provocation test uses chelating agent and conducting to appropriate therapy according to the result. but, indications for the therapy of chelating agents with mercury exposure have not yet been fully established. The therapy to symptomatic patients with mercury poisoning is chelating agents, combination therapy with chelating agents, plasma exchange, hemodialysis, plasmapheresis. But the further evaluations are necessary for the effects and side effects with each therapy.

KEYWORDS:

Diagnosis; Intoxication; Mercury; Treatment

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