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Nat Rev Neurosci. 2016 Feb;17(2):89-102. doi: 10.1038/nrn.2015.22.

Rediscovering area CA2: unique properties and functions.

Author information

1
Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.

Abstract

Hippocampal area CA2 has several features that distinguish it from CA1 and CA3, including a unique gene expression profile, failure to display long-term potentiation and relative resistance to cell death. A recent increase in interest in the CA2 region, combined with the development of new methods to define and manipulate its neurons, has led to some exciting new discoveries on the properties of CA2 neurons and their role in behaviour. Here, we review these findings and call attention to the idea that the definition of area CA2 ought to be revised in light of gene expression data.

PMID:
26806628
PMCID:
PMC4856153
DOI:
10.1038/nrn.2015.22
[Indexed for MEDLINE]
Free PMC Article

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