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Regul Toxicol Pharmacol. 2016 Apr;76:113-20. doi: 10.1016/j.yrtph.2016.01.012. Epub 2016 Jan 22.

Tobacco-specific N-nitrosamines NNN and NNK levels in cigarette brands between 2000 and 2014.

Author information

1
Philip Morris Products SA, Product Development, Rue des Usines 56, 2000 Neuchâtel, Switzerland. Electronic address: irfan.gunduz@pmi.com.
2
Philip Morris Products SA, Product Development, Rue des Usines 56, 2000 Neuchâtel, Switzerland.
3
Philip Morris International Management SA, Product and Process Quality, Quai Jeanrenaud 56, 2000 Neuchâtel, Switzerland.
4
Philip Morris International Management SA, Leaf Agricultural Programs, Avenue de Rhodanie 50, 1001 Lausanne, Switzerland.

Abstract

The evolution of the levels of tobacco-specific N-nitrosamines (TSNA), N-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in mainstream (MS) cigarette smoke is investigated based on smoke and tobacco chemistry data of cigarette brands sold by Philip Morris International (PMI) between 2000 and 2014. A total of 315 cigarette samples representing a wide range of product and design characteristics manufactured by PMI between 2008 and 2014 were analyzed and compared to a previously published dataset of PMI brands manufactured in 2000. The data indicate that there is a substantial reduction of NNN and NNK levels in tobacco fillers and MS cigarette smoke per mg of tar and per mg of nicotine using Health Canada Intense (HCI) machine-smoking regime. This observed reduction in NNN and NNK levels in MS cigarette smoke is also supported by the downward trend observed on NNN and NNK levels in USA flue-cured Virginia and Burley tobacco lots from 2000 to 2014 crops, reflecting effectiveness of measures taken on curing and agricultural practices designed to minimize TSNA formation in tobacco.

KEYWORDS:

Cigarette smoke; NNK; NNN; Smoke transfer; TSNA; Tobacco

PMID:
26806560
DOI:
10.1016/j.yrtph.2016.01.012
[Indexed for MEDLINE]
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