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Microbes Infect. 2016 May;18(5):310-21. doi: 10.1016/j.micinf.2016.01.002. Epub 2016 Jan 22.

Candida albicans biofilms: development, regulation, and molecular mechanisms.

Author information

1
Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, Merced, CA, USA.
2
Department of Molecular and Cell Biology, School of Natural Sciences, University of California, Merced, Merced, CA, USA. Electronic address: cnobile@ucmerced.edu.

Abstract

A major virulence attribute of Candida albicans is its ability to form biofilms, densely packed communities of cells adhered to a surface. These biofilms are intrinsically resistant to conventional antifungal therapeutics, the host immune system, and other environmental factors, making biofilm-associated infections a significant clinical challenge. Here, we review current knowledge on the development, regulation, and molecular mechanisms of C. albicans biofilms.

KEYWORDS:

Biofilm; Candida albicans; Fungi; Microbial community; Pathogen; Transcriptional regulation

PMID:
26806384
PMCID:
PMC4860025
DOI:
10.1016/j.micinf.2016.01.002
[Indexed for MEDLINE]
Free PMC Article

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