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Support Care Cancer. 2016 Jun;24(6):2735-41. doi: 10.1007/s00520-016-3084-7. Epub 2016 Jan 25.

Results of 20- versus 45-min post-infusion scalp cooling time in the prevention of docetaxel-induced alopecia.

Author information

1
Department of Internal Medicine and Medical Oncology, Medical Centre Alkmaar, PO Box 501, 1800, AM, Alkmaar, The Netherlands. manon.komen@mca.nl.
2
Give Hair a Chance Foundation, Research Department, Knowledge Institute Scalp Cooling, PO Box 231, 5600, AE, Eindhoven, The Netherlands.
3
Department of Medical Oncology, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066, CX, Amsterdam, The Netherlands.
4
Science Department, Medical Centre Alkmaar, PO Box 501, 1800, AM, Alkmaar, The Netherlands.
5
Department of Internal Medicine, Twee Steden ziekenhuis, Dr. Deelenlaan 5, 5042, AD, Tilburg, The Netherlands.
6
Department of Medical Oncology, Leiden University Medical Centre, PO Box 9600, 2300, RC, Leiden, The Netherlands.
7
Research Department, The Netherlands Comprehensive Cancer Organisation, PO Box 231, 5600, AE, Eindhoven, The Netherlands.

Abstract

PURPOSE:

For patients, chemotherapy-induced alopecia (CIA) is one of the most distressing side effects of treatment. Scalp cooling can prevent or minimise CIA; the results may depend on the duration of cooling. Since a previous study on post-infusion cooling time in patients treated with docetaxel chemotherapy found no difference between 90 and 45 min, we investigated whether hair-preserving results could be maintained with a shorter post-infusion cooling time.

METHODS:

In this prospective, multi-centre randomised study, 134 patients who started treatment with docetaxel 75-100 mg/m(2) in a 3-weekly schedule were randomly assigned in a 1:1 ratio to a post-infusion cooling time of 45 or 20 min. The primary end point was the need for a wig or other head covering as assessed by the patient. A visual analogue scale (VAS) with a range from 0 (not tolerable) to 10 (very tolerable) was used to measure tolerance.

RESULTS:

Scalp cooling results were similar for 45- and 20-min post-infusion cooling times. Thirty-three out of 45 patients (73 %) treated with 20 min of post-infusion cooling did not need a form of head covering, compared with 41 out of 52 patients (79 %) treated with 45 min of post-infusion cooling (p = 0.5). The procedure was well tolerated (mean visual analogue score 8.3). Six patients stopped due to intolerance during the first treatment cycle.

CONCLUSIONS:

A 20-min post-infusion cooling time is effective and tolerable for patients treated with scalp cooling to prevent docetaxel-induced alopecia.

TRIAL REGISTRATION:

Trialregister.nl Identifier, NTR 1856.

KEYWORDS:

Alopecia; Chemotherapy; Docetaxel; Scalp cooling; Side effects

PMID:
26805558
DOI:
10.1007/s00520-016-3084-7
[Indexed for MEDLINE]

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