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Skin Res Technol. 2016 Nov;22(4):395-405. doi: 10.1111/srt.12277. Epub 2016 Jan 25.

Comparison of different optical coherence tomography devices for diagnosis of non-melanoma skin cancer.

Author information

1
Department of Dermatology and Allergology, General Hospital Augsburg, Augsburg, Germany.
2
Department of Dermatology and Allergology, Ludwig-Maximilian University of Munich, Munich, Germany.
3
Department of Dermatology and Allergology, General Hospital Augsburg, Augsburg, Germany. julia.welzel@klinikum-augsburg.de.

Abstract

PURPOSE:

To compare the diagnostic imaging ability of three different optical coherence tomography (OCT) devices in non-melanoma skin cancer (NMSC).

METHODS:

Thirty actinic keratoses (AKs) and 27 basal cell carcinomas (BCCs) of 29 patients were examined with three different OCT devices, VivoSight® , Callisto® and Skintell® .

RESULTS:

Complete data sets were available for 16 BCCs and 10 AKs of 18 patients. All OCT devices were able to discriminate BCCs and AKs significantly from perilesional normal skin due to lower signal intensities as well as a thicker stratum corneum and epidermis in AKs. A significant decrease in the signal intensity and thickness of all skin layers was noted with Skintell® in contrast to VivoSight® and Callisto® . OCT comparisons revealed only slight differences between VivoSight® and Callisto® . Regarding BCC tumor thickness VivoSight® and Callisto® correlated well, histology did not correlate with the three OCT devices, whereas Skintell® showed no correlation with VivoSight® , Callisto® or histology.

CONCLUSION:

All tested OCT devices could identify BCCs and AKs objectively through standardized measurement of signal intensity and skin layer thickness. Due to their technical specifications (resolution, penetration depth), each of the OCT systems offers additional and special information on NMSC.

KEYWORDS:

OCT devices; actinic keratosis; basal cell carcinoma; non-melanoma skin cancer; optical coherence tomography; skin imaging

PMID:
26804618
DOI:
10.1111/srt.12277
[Indexed for MEDLINE]

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