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Immunol Lett. 2016 Mar;171:26-35. doi: 10.1016/j.imlet.2016.01.006. Epub 2016 Jan 22.

Atypical IκB proteins in immune cell differentiation and function.

Author information

1
Institute of Molecular and Clinical Immunology, Otto-von-Guericke University, Leipziger Straße 44, 39120 Magdeburg, Germany.
2
Institute of Molecular and Clinical Immunology, Otto-von-Guericke University, Leipziger Straße 44, 39120 Magdeburg, Germany; Research Group of Systems-Oriented Immunology and Inflammation Research, Helmholtz Centre for Infection Research, Inhoffenstraße 7, 38124 Braunschweig, Germany.
3
Institute of Molecular and Clinical Immunology, Otto-von-Guericke University, Leipziger Straße 44, 39120 Magdeburg, Germany; Department of Immune Control, Helmholtz Centre for Infection Research, Inhoffenstraße 7, 38124 Braunschweig, Germany.
4
Institute of Molecular and Clinical Immunology, Otto-von-Guericke University, Leipziger Straße 44, 39120 Magdeburg, Germany; Research Group of Systems-Oriented Immunology and Inflammation Research, Helmholtz Centre for Infection Research, Inhoffenstraße 7, 38124 Braunschweig, Germany. Electronic address: ingo.schmitz@helmholtz-hzi.de.

Abstract

The NF-κB/Rel signalling pathway plays a crucial role in numerous biological processes, including innate and adaptive immunity. NF-κB is a family of transcription factors, whose activity is regulated by the inhibitors of NF-κB (IκB). The IκB proteins comprise two distinct groups, the classical (cytoplasmic) and the atypical (nuclear) IκB proteins. Although the cytoplasmic regulation of NF-κB is well characterised, its nuclear regulation mechanisms remain marginally elucidated. However, work from recent years indicated that nuclear IκBs contribute significantly to the modulation of NF-κB-mediated transcription in the immune system. Here, we discuss the role of the atypical IκB proteins Bcl-3, IκBζ, IκBNS, IκBη and IκBL for the regulation of gene expression and effector functions in immune cells.

KEYWORDS:

Atypical IkappaB; Immune system; Macrophage; NF-kappaB; T cell

PMID:
26804211
DOI:
10.1016/j.imlet.2016.01.006
[Indexed for MEDLINE]

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