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BMC Complement Altern Med. 2016 Jan 22;16:19. doi: 10.1186/s12906-016-0997-0.

Hepatoprotective effect of licorice, the root of Glycyrrhiza uralensis Fischer, in alcohol-induced fatty liver disease.

Author information

1
Life Science Research Institute, Novarex Co., Ltd, Ochang, Cheongwon, Chungbuk, 363-885, Republic of Korea.
2
College of Pharmacy, Yonsei University, Incheon, 406-840, Republic of Korea.
3
College of Pharmacy, Pusan National University, Busan, 609-735, Republic of Korea.
4
Department of Biomedical Laboratory Science, Daekyeung College, Gyeongsan, 712-719, Republic of Korea.
5
Department of Molecular Medicine and Tissue Injury Defense Research Center, School of Medicine, Ewha Woman's University, Seoul, 158-710, Republic of Korea.
6
College of Pharmacy, Pusan National University, Busan, 609-735, Republic of Korea. youngjung@pusan.ac.kr.

Abstract

BACKGROUND:

Our previous study suggested that licorice has anti-inflammatory activity in lipopolysaccharide-stimulated microglial cells and anti-oxidative activity in tert-butyl hydroperoxide-induced oxidative liver damage. In this study, we evaluated the effect of licorice on chronic alcohol-induced fatty liver injury mediated by inflammation and oxidative stress.

METHODS:

Raw licorice was extracted, and quantitative and qualitative analysis of its components was performed by using LC-MS/MS. Mice were fed a liquid alcohol diet with or without licorice for 4 weeks.

RESULTS:

We have standardized 70% fermented ethanol extracted licorice and confirmed by LC-MS/MS as glycyrrhizic acid (GA), 15.77 ± 0.34 μg/mg; liquiritin (LQ), 14.55 ± 0.42 μg/mg; and liquiritigenin (LG), 1.34 ± 0.02 μg/mg, respectively. Alcohol consumption increased serum alanine aminotransferase and aspartate aminotransferase activities and the levels of triglycerides and tumor necrosis factor (TNF)-α. Lipid accumulation in the liver was also markedly induced, whereas the glutathione level was reduced. All these alcohol-induced changes were effectively inhibited by licorice treatment. In particular, the hepatic glutathione level was restored and alcohol-induced TNF-α production was significantly inhibited by licorice.

CONCLUSION:

Taken together, our data suggests that protective effect of licorice against alcohol-induced liver injury may be attributed to its anti-inflammatory activity and enhancement of antioxidant defense.

PMID:
26801973
PMCID:
PMC4722619
DOI:
10.1186/s12906-016-0997-0
[Indexed for MEDLINE]
Free PMC Article

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