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Pigment Cell Melanoma Res. 2016 May;29(3):284-96. doi: 10.1111/pcmr.12454.

Zebrafish Leucocyte tyrosine kinase controls iridophore establishment, proliferation and survival.

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Max-Planck-Institut für Entwicklungsbiologie, Tübingen, Germany.


The zebrafish striped pattern results from the interplay among three pigment cell types; black melanophores, yellow xanthophores and silvery iridophores, making it a valuable model to study pattern formation in vivo. It has been suggested that iridophore proliferation, dispersal and cell shape transitions play an important role during stripe formation; however, the underlying molecular mechanisms remain poorly understood. Using gain- and loss-of-function alleles of leucocyte tyrosine kinase (ltk) and a pharmacological inhibitor approach, we show that Ltk specifically regulates iridophore establishment, proliferation and survival. Mutants in shady/ltk lack iridophores and display an abnormal body stripe pattern. Moonstone mutants, ltk(mne) , display ectopic iridophores, suggesting hyperactivity of the mutant Ltk. The dominant ltk(mne) allele carries a missense mutation in a conserved position of the kinase domain that highly correlates with neuroblastomas in mammals. Chimeric analysis suggests a novel physiological role of Ltk in the regulation of iridophore proliferation by homotypic competition.


homotypic competition; iridophores; leucocyte tyrosine kinase; pigment cells; tumorigenesis; zebrafish

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