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Muscle Nerve. 2016 Apr;53(4):641-3. doi: 10.1002/mus.25044. Epub 2016 Feb 23.

Skin biopsy in assessing meralgia paresthetica.

Author information

1
Department of Neurology, Icahn Medical School of Mount Sinai, 1468 Madison Avenue, Box 1052, New York, New York, 10029, USA.

Abstract

INTRODUCTION:

Meralgia paresthetica is a focal neuropathy caused by compression of the lateral femoral cutaneous nerve (LFCN). The disease can be difficult to assess by neurophysiological or imaging studies.

METHODS:

We studied 5 patients who presented to our neuromuscular clinic from April 2012 to December 2014 with a clinical suspicion of meralgia paresthetica and had skin biopsies with intraepidermal nerve fiber density (IENFD) evaluation.

RESULTS:

The mean age at onset was 37.2 (range 21-59) years. There were 4 women and 1 man. Two were obese, 2 wore tight jeans, and 1 had mild diabetes mellitus. IENFD was reduced in the symptomatic proximal thigh in all 5 patients and was also reduced in the asymptomatic thigh in 2 patients. It was normal in the distal leg in 4 patients.

CONCLUSION:

Meralgia paresthetica is associated with loss of small intraepidermal nerve fibers. Skin biopsy with IENFD evaluation may be a useful diagnostic tool for this disease.

KEYWORDS:

diagnosis; intraepidermal nerve fiber density; lateral femoral cutaneous nerve; meralgia paresthetica; skin biopsy

PMID:
26800390
DOI:
10.1002/mus.25044
[Indexed for MEDLINE]

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