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J Magn Reson Imaging. 2016 Aug;44(2):426-32. doi: 10.1002/jmri.25144. Epub 2016 Jan 22.

Longitudinal change in magnetic susceptibility of new enhanced multiple sclerosis (MS) lesions measured on serial quantitative susceptibility mapping (QSM).

Author information

1
Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China.
2
Department of Neurology, Weill Cornell Medical College, New York, New York, USA.
3
Department of Radiology, Weill Cornell Medical College, New York, New York, USA.
4
Department of Healthcare Policy & Research, Weill Cornell Medical College, New York, New York, USA.
5
Department of Biomedical Engineering, Cornell University, Ithaca, New York, USA.

Abstract

PURPOSE:

To measure the longitudinal change in multiple sclerosis (MS) lesion susceptibility using quantitative susceptibility mapping (QSM).

MATERIALS AND METHODS:

The study was approved by our Institutional Review Board. Longitudinal changes in quantitative susceptibility values of new enhanced-with-Gd MS lesions were measured at baseline magnetic resonance imaging (MRI) and on a follow-up MRI in 29 patients within 2 years using a 3D multiple echo gradient echo sequence on a 3T scanner. Paired t-test and the generalized estimating equations (GEE) model was used to analyze the longitudinal change.

RESULTS:

Lesion susceptibility values relative to normal-appearing white matter (NAWM) changed from 3.61 ± 6.11 ppb when enhanced-with-Gd at the baseline MRI to 20.42 ± 10.23 ppb when not-enhanced-with-Gd at the follow-up MRI (P < 0.001).

CONCLUSION:

MS lesion susceptibility value increases significantly as the lesion evolves from enhanced-with-Gd to not-enhanced-with-Gd, serving as a disease biomarker. J. Magn. Reson. Imaging 2016;44:426-432.

KEYWORDS:

gadolinium enhancement; longitudinal change; magnetic resonance imaging; multiple sclerosis; quantitative susceptibility mapping (QSM)

PMID:
26800367
PMCID:
PMC4946979
DOI:
10.1002/jmri.25144
[Indexed for MEDLINE]
Free PMC Article

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