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Struct Dyn. 2015 Apr 21;2(4):041701. doi: 10.1063/1.4918726. eCollection 2015 Jul.

The linac coherent light source single particle imaging road map.

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Center for Free-Electron Laser Science, DESY , Notkestr. 85, 22607 Hamburg, Germany.
SLAC National Accelerator Laboratory , 2575 Sand Hill Road, Menlo Park, California 94025, USA.
Lawrence Berkeley National Laboratory , 1 Cyclotron Rd., Berkeley, California 94720, USA.
PULSE Institute , SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025, USA.
Lawrence Livermore National Laboratory , Livermore, California 94550, USA.
Department of Physics, University of Wisconsin Milwaukee , 1900 E. Kenwood Blvd, Milwaukee, Wisconsin 53211, USA.
Max Planck Institute for Medical Research , Jahnstrasse 29, 69120 Heidelberg, Germany.
Deutsches Elektronen-Synchrotron DESY , Notkestraße 85, 22607 Hamburg, Germany.
Department of Physics, Arizona State University , Rural Rd, Tempe, Arizona 85287, USA.
School of Medicine, Stanford University , 299 Campus Drive, Stanford, California 94305, USA.


Intense femtosecond x-ray pulses from free-electron laser sources allow the imaging of individual particles in a single shot. Early experiments at the Linac Coherent Light Source (LCLS) have led to rapid progress in the field and, so far, coherent diffractive images have been recorded from biological specimens, aerosols, and quantum systems with a few-tens-of-nanometers resolution. In March 2014, LCLS held a workshop to discuss the scientific and technical challenges for reaching the ultimate goal of atomic resolution with single-shot coherent diffractive imaging. This paper summarizes the workshop findings and presents the roadmap toward reaching atomic resolution, 3D imaging at free-electron laser sources.

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