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Vaccine. 2016 Feb 10;34(7):881-6. doi: 10.1016/j.vaccine.2016.01.004. Epub 2016 Jan 13.

Assessment of safety and interferon gamma responses of Mycobacterium bovis BCG vaccine in goat kids and milking goats.

Author information

1
Centre de Recerca en Sanitat Animal (CReSA)-Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Campus UAB, Bellaterra, 08193 Barcelona, Catalonia, Spain. Electronic address: bernat.perez@irta.cat.
2
Centre de Recerca en Sanitat Animal (CReSA)-Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Campus UAB, Bellaterra, 08193 Barcelona, Catalonia, Spain.
3
Departament de Sanitat i Anatomia Animals, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Catalonia, Spain.
4
Departament d'Agricultura, Ramaderia, Pesca i Alimentació de la Generalitat de Catalunya, 08007 Barcelona, Catalonia, Spain.
5
Lionex Diagnostics and Therapeutics GmbH, D-38126 Braunschweig, Germany.
6
Thermo Fisher Scientific, Schlieren, 8952 Zürich, Switzerland.
7
Centre de Recerca en Sanitat Animal (CReSA)-Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Campus UAB, Bellaterra, 08193 Barcelona, Catalonia, Spain; Departament de Sanitat i Anatomia Animals, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Catalonia, Spain.

Abstract

Vaccination of domestic animals has emerged as an alternative long-term strategy for the control of tuberculosis (TB). A trial under field conditions was conducted in a TB-free goat herd to assess the safety of the Mycobacterium bovis BCG vaccine. Eleven kids and 10 milking goats were vaccinated with BCG. Bacterial shedding and interferon gamma (IFN-γ) responses were monitored throughout the study. Comprehensive pathological examination and mycobacterial culture of target tissues were performed. BCG vaccine strain was only isolated from the draining lymph node of the injection site of a kid euthanized at week 8 post-vaccination. The remaining animals were euthanized at week 24. Six out of 20 showed small granulomas at the injection site. BCG shedding was not detected in either faeces or in milk throughout the study. All vaccinated kids showed BCG-induced IFN-γ responses at week 8 post-vaccination. BCG vaccination of goats showed no lack of biological safety for the animals, environment and public health, and local adverse reactions were negligible.

KEYWORDS:

BCG; DIVA; Goats; Interferon gamma; Safety; Tuberculosis

PMID:
26795364
DOI:
10.1016/j.vaccine.2016.01.004
[Indexed for MEDLINE]

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