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Seizure. 2016 Feb;35:45-9. doi: 10.1016/j.seizure.2016.01.003. Epub 2016 Jan 7.

Different calorie restriction treatments have similar anti-seizure efficacy.

Author information

1
Department Medicine and Surgery, University of Salerno, via Allende snc, Baronissi (SA), Italy. Electronic address: aviggiano@unisa.it.
2
Department of Molecular Pharmacology and Physiology, Hyperbaric Biomedical Research Laboratory, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., MDC 8 Tampa, FL, United States; External Pharmacy of Fatebenefratelli Hospital, Viale Principe di Napoli 14/A, Benevento, Italy. Electronic address: raf.pilla@gmail.com.
3
Savind, Inc., Seymour, IL, United States.
4
Department of Experimental Medicine, Second University of Naples, Italy. Electronic address: marcellino.monda@unina2.it.
5
Department of Molecular Pharmacology and Physiology, Hyperbaric Biomedical Research Laboratory, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd., MDC 8 Tampa, FL, United States. Electronic address: ddagosti@health.usf.edu.
6
Department Medicine and Surgery, University of Salerno, via Allende snc, Baronissi (SA), Italy.
7
Department Medicine and Surgery, University of Salerno, via Allende snc, Baronissi (SA), Italy; UO Child and Adolescent Neuropsychiatry, Medical School, University of Salerno, Largo Città di Ippocrate snc, Salerno, Italy.

Abstract

PURPOSE:

Previous studies showed that a single oral administration of a synthetic ketone ester (1,3-butanediol acetoacetate diester, BD-AcAc2) could elevate blood ketones with promising acute anti-epileptic effects. The aim of the present work was to evaluate the tolerability of a prolonged administration of BD-AcAc2 and the anti-epileptic efficacy of such treatment.

METHODS:

The threshold for seizure induction with progressive intravenous infusion of pentylenetrazole (PTZ) was evaluated in anesthetized Wistar rats after a ten-day oral administration of BD-AcAc2 (gavage). The effects of this treatment were compared to those of: (1) a ten-day water gavage administration, (2) a ten-day ketogenic diet, (3) a standard rodent chow diet.

RESULTS:

Compared to the standard diet, all other treatments produced a calorie restriction and an elevation of the seizure threshold.

CONCLUSION:

These results indicate that supplementation with an oral synthetic ketone can have anti-seizure effects, but the formulation has to be further ameliorated to be more palatable; further studies are also needed to better understand the role played by ketone bodies alone in vivo, without any calorie restriction.

KEYWORDS:

Calorie restriction; Ketogenic diet; Seizure; Synthetic ketone

PMID:
26794009
DOI:
10.1016/j.seizure.2016.01.003
[Indexed for MEDLINE]
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