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Urol Case Rep. 2015 Aug 12;3(6):179-80. doi: 10.1016/j.eucr.2015.07.006. eCollection 2015 Nov.

Testosterone Replacement Therapy in Adolescents With Sickle Cell Disease Reverses Hypogonadism Without Promoting Priapism: A Case Report.

Author information

1
Department of Surgery, University of the West Indies, Mona, Kingston 7, Jamaica.
2
Sickle Cell Unit, University of the West Indies, Mona, Kingston 7, Jamaica.
3
Department of Paediatrics, University of the West Indies, Mona, Kingston 7, Jamaica.

Abstract

Delayed puberty secondary to hypogonadism is commonly seen in sickle cell disease (SCD), affecting normal growth and development. The condition is rarely treated in SCD for fear of inducing priapism episodes. We present a case report of an Afro-Jamaican adolescent male at 16 years of age who presented with symptoms of delayed puberty as well as frequent stuttering priapism episodes. Endocrinological assessment revealed low serum total testosterone levels. Treatment was commenced monthly with testosterone enanthate which resulted in improved symptoms of delayed puberty, improvement in anthropometric parameters while apparently ameliorating priapism episodes.

KEYWORDS:

Hypogonadism; Priapism; Sickle cell disease; Testosterone

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