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Trop Doct. 2017 Jan;47(1):6-10. Epub 2016 Jan 20.

Prevalence of hypothyroidism in rheumatoid arthritis and its correlation with disease activity.

Author information

1
Assistant Professor, Department of Medicine, Sri Aurobindo Medical College and Post Graduate Institute, Indore, Madhya Pradesh, India.
2
Junior Resident, Department of Medicine, Sri Aurobindo Medical College and Post Graduate Institute, Indore, Madhya Pradesh, India docaagarwal@gmail.com.
3
Junior Resident, Department of Medicine, Sri Aurobindo Medical College and Post Graduate Institute, Indore, Madhya Pradesh, India.
4
Scientist Central Research Laboratory, Sri Aurobindo Medical College and Post Graduate Institute, Indore, Madhya Pradesh, India.

Abstract

OBJECTIVES:

To analyse the prevalence of hypothyroidism in rheumatoid arthritis (RA) patients and to elucidate its correlation with disease activity.

METHODS:

A total of 52 RA patients were enrolled in this study. All patients were assessed fully clinically and underwent routine laboratory investigation including thyroid function testing.

RESULTS:

Hypothyroidism (defined as having a TSH level >4.20 μIU/mL) was observed in 20/52 (38.4%). Erythrocyte sedimentation rates (ESR) were found significantly elevated in patients with hypothyroidism compared to those without (36.3 ± 24.2 vs. 24.6 ± 9.0 mm/h). Disease activity parameters such as DAS-28-ESR, tender joint count; VAS scores were also significantly higher in the former. A significant correlation with serum TSH levels was observed with ESR and DAS-28-ESR.

CONCLUSION:

Thyroid function test should be included in clinical evaluation of RA patients.

KEYWORDS:

Autoimmune thyroid disease; disease activity score; hypothyroidism; rheumatoid arthritis (RA)

PMID:
26792597
DOI:
10.1177/0049475515627235
[Indexed for MEDLINE]

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