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Brain. 2016 Mar;139(Pt 3):795-806. doi: 10.1093/brain/awv386. Epub 2016 Jan 20.

Brain intra- and extracellular sodium concentration in multiple sclerosis: a 7 T MRI study.

Author information

1
1 Department of Neurology, Icahn School of Medicine, Mount Sinai, New York, USA 2 Department of Neuroscience, Reproductive and Odontostomatological Sciences, Federico II University, Naples, Italy.
2
1 Department of Neurology, Icahn School of Medicine, Mount Sinai, New York, USA.
3
3 Department of Radiology, Icahn School of Medicine, Mount Sinai, New York, USA.
4
1 Department of Neurology, Icahn School of Medicine, Mount Sinai, New York, USA 4 Department of Anatomy and Neurosciences, VU University Medical Center, Amsterdam, The Netherlands.
5
5 Siemens Healthcare, New York, USA.
6
1 Department of Neurology, Icahn School of Medicine, Mount Sinai, New York, USA 3 Department of Radiology, Icahn School of Medicine, Mount Sinai, New York, USA 6 Department of Neuroscience, Icahn School of Medicine, Mount Sinai, New York, USA 7 Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.

Abstract

Intra-axonal accumulation of sodium ions is one of the key mechanisms of delayed neuro-axonal degeneration that contributes to disability accrual in multiple sclerosis. In vivo sodium magnetic resonance imaging studies have demonstrated an increase of brain total sodium concentration in patients with multiple sclerosis, especially in patients with greater disability. However, total sodium concentration is a weighted average of intra- and extra-cellular sodium concentration whose changes reflect different tissue pathophysiological processes. The in vivo, non-invasive measurement of intracellular sodium concentration is quite challenging and the few applications in patients with neurological diseases are limited to case reports and qualitative assessments. In the present study we provide first evidence of the feasibility of triple quantum filtered (23)Na magnetic resonance imaging at 7 T, and provide in vivo quantification of global and regional brain intra- and extra-cellular sodium concentration in 19 relapsing-remitting multiple sclerosis patients and 17 heathy controls. Global grey matter and white matter total sodium concentration (respectively P < 0.05 and P < 0.01), and intracellular sodium concentration (both P < 0.001) were higher while grey matter and white matter intracellular sodium volume fraction (indirect measure of extracellular sodium concentration) were lower (respectively P = 0.62 and P < 0.001) in patients compared with healthy controls. At a brain regional level, clusters of increased total sodium concentration and intracellular sodium concentration and decreased intracellular sodium volume fraction were found in several cortical, subcortical and white matter regions when patients were compared with healthy controls (P < 0.05 family-wise error corrected for total sodium concentration, P < 0.05 uncorrected for multiple comparisons for intracellular sodium concentration and intracellular sodium volume fraction). Measures of total sodium concentration and intracellular sodium volume fraction, but not measures of intracellular sodium concentration were correlated with T2-weighted and T1-weighted lesion volumes (0.05 < P < 0.01) and with Expanded Disability Status Scale (P < 0.05). Thus, suggesting that while intracellular sodium volume fraction decrease could reflect expansion of extracellular space due to tissue loss, intracellular sodium concentration increase could reflect neuro-axonal metabolic dysfunction.

KEYWORDS:

intra-cellular and extra-cellular sodium concentration; relapsing-remitting multiple sclerosis; sodium imaging; ultra-high field MRI

PMID:
26792552
DOI:
10.1093/brain/awv386
[Indexed for MEDLINE]

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