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J Neuropsychiatry Clin Neurosci. 2016 Jan 21:appineuropsych15090240. [Epub ahead of print]

Default Mode Network Functional Reorganization During Early Abstinence in Polysubstance-Using Emerging Adults Treated for Opioid Dependence.

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From the Division of Alcohol and Drug Abuse, McLean Hospital, Belmont, MA (MLC, JSP, KHF, GDV, BdeBF, SEL, RDW, ACJ); and the Dept. of Psychiatry, Harvard Medical School, Boston, MA (MLC, JSP, GDV, BdeBF, SEL, RDW, ACJ).


This study examined default mode network connectivity within the first 30 days of abstinence in emerging adults entering treatment for opioid dependence. There were significant associations between abstinence duration and coupling strength with brain regions within and outside of the network.

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