Format

Send to

Choose Destination
Regul Toxicol Pharmacol. 2016 Apr;76:211-2. doi: 10.1016/j.yrtph.2016.01.001. Epub 2016 Jan 11.

Opinion of the Scientific Committee on Consumer safety (SCCS) - Opinion on the safety of the use of Methylisothiazolinone (MI) (P94), in cosmetic products (sensitisation only).

Author information

1
SCCS Secretariat at the European Commission, Directorate General for Health and Food Safety, 11, rue E. Ruppert, L-2920 Luxembourg, Luxembourg. Electronic address: SANTE-C2-SCCS@ec.europa.eu.
2
Department of Dermatology, Hospital del Mar. Parc de Salut Mar. Universitat Autònoma, Barcelona, Spain.

Abstract

The information provided does not support the safe use of MI as a preservative in rinse-off cosmetic products up to a concentration limit of 100 ppm from the view of induction of contact allergy. For rinse-off cosmetic products, a concentration of 15 ppm (0.0015%) MI is considered safe for the consumer from the point of view of induction of contact allergy. The information provided does not support the safe use of MI as a preservative in leave-on hair cosmetic products up to a concentration limit of 100 ppm from the point of view of induction of contact allergy. The concerns and opinions raised in SCCS Opinion SCCS/1521/13 (12 December 2013 with revision 27 March 2014) remain. The results of the recent Scandinavian study do not support safety of MI in rinse-off products at either 100 ppm or at 50 ppm for elicitation or induction.

KEYWORDS:

CAS 2682-20-4; EC 220-239-6; Methylisothiazolinone (MI) (P94); Regulation 1223/2009; SCCS; Scientific opinion; Sensitisation

PMID:
26790577
DOI:
10.1016/j.yrtph.2016.01.001
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center