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Nat Rev Mol Cell Biol. 2016 Apr;17(4):240-56. doi: 10.1038/nrm.2015.16. Epub 2016 Jan 21.

Mechanisms of ephrin-Eph signalling in development, physiology and disease.

Kania A1,2,3, Klein R4,5.

Author information

1
Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Quebec H2W 1R7, Canada.
2
Département de Médecine, Université de Montréal, Montréal, Quebec H3T 1J4, Canada.
3
Division of Experimental Medicine, Departments of Biology, Anatomy and Cell Biology, and Integrated Program in Neurosciences, McGill University, Montréal, Quebec H3A 1A3, Canada.
4
Department of Molecules - Signaling - Development, Max Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 Martinsried, Germany.
5
Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.

Abstract

Eph receptor Tyr kinases and their membrane-tethered ligands, the ephrins, elicit short-distance cell-cell signalling and thus regulate many developmental processes at the interface between pattern formation and morphogenesis, including cell sorting and positioning, and the formation of segmented structures and ordered neural maps. Their roles extend into adulthood, when ephrin-Eph signalling regulates neuronal plasticity, homeostatic events and disease processes. Recently, new insights have been gained into the mechanisms of ephrin-Eph signalling in different cell types, and into the physiological importance of ephrin-Eph in different organs and in disease, raising questions for future research directions.

PMID:
26790531
DOI:
10.1038/nrm.2015.16
[Indexed for MEDLINE]

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