Format

Send to

Choose Destination
Muscle Nerve. 2016 Aug;54(2):220-7. doi: 10.1002/mus.25027. Epub 2016 Feb 8.

P/Q- and N-type calcium-channel antibodies: Oncological, neurological, and serological accompaniments.

Author information

1
Department of Neurology, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
2
Department of Laboratory Medicine and Pathology, College of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
3
Department of Immunology, College of Medicine, Mayo Clinic, 200 First Street SW, Rochester, Minnesota, 55905, USA.

Abstract

INTRODUCTION:

Voltage-gated calcium-channel autoimmunity (VGCC-P/Q and VGCC-N types) occurs beyond Lambert-Eaton syndrome and lung cancer.

METHODS:

We reviewed records for 236 Mayo Clinic patients with VGCC antibodies found in evaluation for paraneoplastic neurological autoimmunity (generally without myasthenic syndromes).

RESULTS:

VGCC autoantibodies were detected in 3.4% of neurological patients, 1.7% of healthy controls, and 4% of neurologically asymptomatic lung cancer controls. Fifty neurological patients (21%) had ≥ 1 neoplasm, historically (46) or detected prospectively [small-cell lung carcinoma (2), breast adenocarcinoma (2), lymphoma (1), and suspected tonsillar carcinoma (1)]. Autoimmune neurological diagnosis frequencies (encephalopathy, ataxia, myelopathy, neuropathy, neuromuscular junction disorder, and myopathy) among patients with medium values (24%; 0.10-0.99 nmol/L) or low values (19%; 0.03-0.10 nmol/L) were fewer than among patients with antibody values exceeding 1.00 nmol/L (71%; P = 0.02 and 0.004, respectively).

CONCLUSIONS:

Among neuronal VGCC-autoantibody-seropositive patients, autoimmune neurological phenotypes and cancer types are diverse. Cautious interpretation of results (particularly medium and low values) is advised. Muscle Nerve, 2016 Muscle Nerve 54: 220-227, 2016.

KEYWORDS:

ataxia; calcium channel; myasthenia; neuropathy; paraneoplastic

PMID:
26789908
PMCID:
PMC4940238
DOI:
10.1002/mus.25027
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center