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Expert Opin Drug Saf. 2016;15(4):457-65. doi: 10.1517/14740338.2016.1140743. Epub 2016 Feb 6.

Long-term side effects of glucocorticoids.

Author information

1
a Massachusetts Eye Research and Surgery Institution (MERSI) , Waltham , MA , USA.
2
b Ocular Immunology and Uveitis Foundation , Waltham , MA , USA.
3
c Istanbul Faculty of Medicine, Department of Ophthalmology , Istanbul University , Istanbul , Turkey.
4
d Department of Ophthalmology , Harvard Medical School , Boston , MA , USA.

Abstract

INTRODUCTION:

Glucocorticoids represent the standard therapy for reducing inflammation and immune activation in various diseases. However, as with any potent medication, they are not without side effects. Glucocorticoid-associated side effects may involve most major organ systems. Musculoskeletal, gastrointestinal, cardiovascular, endocrine, neuropsychiatric, dermatologic, ocular, and immunologic side effects are all possible.

AREAS COVERED:

This article analyzes English-language literature and provides an update on the most recent literature regarding side effects of systemic glucocorticoid treatment.

EXPERT OPINION:

The risk/benefit ratio of glucocorticoid therapy can be improved by proper use. Careful monitoring and using appropriate preventive strategies can potentially minimize side effects.

KEYWORDS:

corticosteroids; glucocorticoids; immunosuppression; side effects

PMID:
26789102
DOI:
10.1517/14740338.2016.1140743
[Indexed for MEDLINE]

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