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Appl Physiol Nutr Metab. 2016 Feb;41(2):224-7. doi: 10.1139/apnm-2015-0456. Epub 2015 Oct 29.

Effect of a high and low dose of caffeine on human lymphocyte activation in response to antigen stimulation.

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a AUT University, Sports Performance Research Institute New Zealand, Private Bag 92006, Auckland 1020, New Zealand.
b School of Sport, Exercise, and Health Sciences, Loughborough University, Loughborough, Leicestershire LE11 3TU, UK.


This study investigated the effect of caffeine on antigen-stimulated lymphocyte activation. Six males rested for 3.5 h after ingesting 0 (PLA), 2, or 6 (6CAF) mg·kg(-1) body mass of caffeine. The number of antigen-stimulated NK CD69(+) cells increased in 6CAF at 1 h compared with PLA (P = 0.021). Caffeine did not influence the number of antigen-stimulated CD69(+) T cells or the geometric mean fluorescence intensity expression of CD69 on antigen-stimulated lymphocytes, suggesting caffeine has little effect on antigen-stimulated lymphocyte activation.


CD69; NK cell; T cell; caffeine; caféine; cellules NK; cellules T; immune; lymphocytes; methylxanthine; méthylxanthine

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