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J Immunother Cancer. 2016 Jan 19;4:3. doi: 10.1186/s40425-016-0107-3. eCollection 2016.

Novel technologies and emerging biomarkers for personalized cancer immunotherapy.

Author information

  • 1Memorial Sloan-Kettering Cancer Center, 1275 New York Ave Box 386, New York, NY 10065 USA.
  • 2Genentech, Inc., 1 DNA Way South, San Francisco, CA 94080 USA.
  • 3Bristol-Myers Squibb, 3551 Lawrenceville Road, Princeton, NJ 08648 USA.
  • 4Center of Experimental Therapeutics and Ludwig Institute of Cancer Research, University Hospital of Lausanne, Rue du Bugnon 21, 1011 Lausanne, Switzerland ; Department of Pathology, University of Athens Medical School, "Attikon" University Hospital, 1st Rimini St, 12462 Haidari, Greece.
  • 5Center of Experimental Therapeutics and Ludwig Institute of Cancer Research, University Hospital of Lausanne, Rue du Bugnon 21, 1011 Lausanne, Switzerland.
  • 6Epiontis GmbH, Rudower Chaussee 29, 12489 Berlin, Germany.
  • 7Netherlands Cancer Institute, Postbus 90203, 1006 BE Amsterdam, Netherlands.
  • 8Italian Network for Biotherapy of Tumors (NIBIT)-Laboratory, c/o Medical Oncology and Immunotherapy, University Hospital of Siena, V.le Bracci,16, Siena, 53100 Italy.
  • 9Stanford University Medical Center, 299 Campus Drive, Stanford, CA 94303 USA.
  • 10Earle A. Chiles Research Institute, Providence Cancer Center, 4805 NE Glisan Street, Portland, OR 97213 USA.
  • 11Adaptive Technologies, Inc., 1551 Eastlake Avenue East Suite 200, Seattle, WA 98102 USA.
  • 12AstraZeneca, One MedImmune Way, Gaithersburg, MD 20878 USA.
  • 13PerkinElmer, 68 Elm Street, Hopkinton, MA 01784 USA.
  • 14Sidra Medical and Research Center, PO Box 26999, Doha, Qatar.
  • 15University of Pittsburgh Cancer Institute, 5117 Centre Ave, Suite 1.27, Pittsburgh, PA 15213 USA.
  • 16National Cancer Institute, 9609 Medical Center Drive, Rockville, MD 20850 USA.
  • 17Innsbruck Medical University, Medizinische Klinik, Anichstrasse 35, Innsbruck, A-6020 Austria.
  • 18Department of Medicine, Surgery and Immunology, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh, PA 15213 USA.

Abstract

The culmination of over a century's work to understand the role of the immune system in tumor control has led to the recent advances in cancer immunotherapies that have resulted in durable clinical responses in patients with a variety of malignancies. Cancer immunotherapies are rapidly changing traditional treatment paradigms and expanding the therapeutic landscape for cancer patients. However, despite the current success of these therapies, not all patients respond to immunotherapy and even those that do often experience toxicities. Thus, there is a growing need to identify predictive and prognostic biomarkers that enhance our understanding of the mechanisms underlying the complex interactions between the immune system and cancer. Therefore, the Society for Immunotherapy of Cancer (SITC) reconvened an Immune Biomarkers Task Force to review state of the art technologies, identify current hurdlers, and make recommendations for the field. As a product of this task force, Working Group 2 (WG2), consisting of international experts from academia and industry, assembled to identify and discuss promising technologies for biomarker discovery and validation. Thus, this WG2 consensus paper will focus on the current status of emerging biomarkers for immune checkpoint blockade therapy and discuss novel technologies as well as high dimensional data analysis platforms that will be pivotal for future biomarker research. In addition, this paper will include a brief overview of the current challenges with recommendations for future biomarker discovery.

KEYWORDS:

Bioinformatics; Biomarkers; Cancer immunotherapy; Immune checkpoint blockade; Immune monitoring; Task Force; Technology

PMID:
26788324
PMCID:
PMC4717548
DOI:
10.1186/s40425-016-0107-3
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