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Obes Surg. 2016 Sep;26(9):2138-2143. doi: 10.1007/s11695-016-2070-y.

Severe Vitamin D Deficiency Is Not Associated with Liver Damage in Morbidly Obese Patients.

Author information

1
Institut National de la Santé et de la Recherche Médicale (INSERM), U1065, Team 8, "Hepatic Complications in Obesity", Nice, F-06204, Cedex 3, France. rodolphe.anty@laposte.net.
2
Pôle Référence Hépatite C, Hôpital de l'Archet 2, Centre Hospitalier Universitaire of Nice, 151, Route Saint-Antoine de Ginestière, BP 3079, F-06202, Nice, Cedex 3, France. rodolphe.anty@laposte.net.
3
Faculty of Medecine, University of Nice-Sophia-Antipolis, Nice, F-06107, Cedex 2, France. rodolphe.anty@laposte.net.
4
Pôle Référence Hépatite C, Hôpital de l'Archet 2, Centre Hospitalier Universitaire of Nice, 151, Route Saint-Antoine de Ginestière, BP 3079, F-06202, Nice, Cedex 3, France.
5
Institut National de la Santé et de la Recherche Médicale (INSERM), U1065, Team 8, "Hepatic Complications in Obesity", Nice, F-06204, Cedex 3, France.
6
Faculty of Medecine, University of Nice-Sophia-Antipolis, Nice, F-06107, Cedex 2, France.
7
Biological Centre, Centre Hospitalier Universitaire of Nice, Nice, F-06107, Cedex 2, France.

Abstract

BACKGROUND AND AIMS:

A deficiency in vitamin D could be deleterious during chronic liver diseases. However, contradictory data have been published in patients with non-alcoholic fatty liver disease. The aim of the study was to compare the blood level of 25 hydroxy vitamin D (25-OH vitamin D) with the severity of liver lesions, in a large cohort of morbidly obese patients.

PATIENTS AND METHOD:

Three hundred ninety-eight morbidly obese patients had a liver biopsy. The non-alcoholic steatohepatitis (NASH) Clinical Research Network Scoring System Definition and Scores were used. 25-OH vitamin D was evaluated with a Diasorin®Elisa Kit. Logistic regression analyses were performed to obtain predictive factors of the severity of liver histology.

RESULTS:

20.6 % of patients had NASH. The stage of fibrosis was F0 12.9 %, F1 57.36 %, F2 25.32 %, F3 (bridging fibrosis) 3.88 %, and F4 (cirrhosis) 0.52 %. The 25-OH vitamin D level inversely correlated to the NAS (r = 0.12 and p = 0.01) and to steatosis (r = 0.14 and p = 0.007); however, it was not associated with the presence of NASH. The level of vitamin D was significantly lower in patients with significant fibrosis compared to those without (15.9 (11.1-23.5) vs 19.6 (13.7-24.7) ng/ml, p = 0.02). There was an inverse correlation between the severity of fibrosis and the values of 25-OH vitamin D (r = 0.12 and p = 0.01). In a logistic regression analysis, no parameters were independently associated with the severity of fibrosis except the presence of steatohepatitis (1.94 (1.13-3.35) p = 0.017).

CONCLUSION:

Low levels of 25-OH vitamin D were not independently associated with liver damage in morbidly obese patients with non-alcoholic fatty liver diseases (NAFLD).

KEYWORDS:

25 hydroxy vitamin D; Fibrosis; Morbidly obesity; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis

PMID:
26787197
DOI:
10.1007/s11695-016-2070-y
[Indexed for MEDLINE]

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