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Sci Rep. 2016 Jan 20;6:17958. doi: 10.1038/srep17958.

Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference.

Author information

1
Department of Epidemiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37203, USA.
2
Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Shinjuku-ku, Tokyo 1628655, Japan.
3
Center for Genome Science, National Institute of Health, Osong Health Technology Administration Complex, Chungcheongbuk-do, Republic of Korea.
4
Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
5
Department of Geriatric Medicine, Ehime University Graduate School of Medicine, Ehime, Japan.
6
Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
7
Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore.
8
Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, Guangxi, China.
9
Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China.
10
School of Chinese Medicine, China Medical University, Taichung, Taiwan.
11
Department of Medical Genetics, China Medical University Hospital, Taichung, Taiwan.
12
Department of Health and Nutrition Biotechnology, Asia University, Taichung, Taiwan.
13
Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana, USA.
14
Department of Genetics, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
15
Key Laboratory of Environment and Health, Ministry of Education, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
16
Institute for Health Promotion, Yonsei University, Seodaemun-Gu, Seoul 120-749, Korea.
17
Institute for Translational Genomics and Population Sciences, Department of Pediatrics and Medicine, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
18
Department of Endocrinology, the Central Hospital of Xuzhou, Affiliated Hospital of Southeast University, Xuzhou, Jiangsu, China.
19
Department of Clinical Sciences, Genetic &Molecular Epidemiology Unit, Lund University Diabetes Center, Skåne University Hospital, Malmö 205 02, Sweden.
20
Department of Public Health and Clinical Medicine, Unit of Medicine, Umeå University, Umeå 901 87, Sweden.
21
Department of Medical Chemistry, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
22
State Key Laboratory of Molecular Oncology, Cancer Institute &Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
23
Division of Preventive Medicine, Department of Family and Preventive Medicine, University of California, San Diego School of Medicine, San Diego, California, USA.
24
National Center for Genome Medicine, Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
25
Department of Biomedical Science, Hallym University, Gangwon-do, Korea.
26
Department of Preventive Medicine, College of Medicine, Hanyang University, Seoul, Korea.
27
Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
28
Division of Population Genetics, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
29
Human Genetics Center, University of Texas School of Public Health, Houston, Texas, USA.
30
Medical Scientific Research Center, Guangxi Medical University, Nanning, Guangxi 530021, China.
31
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
32
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
33
Department of Nursing, Tsuruga University of Nursing, Tsuruga, Japan.
34
Office of Population Studies Foundation Inc., University of San Carlos, Talamban, Cebu City, Philippines.
35
Saw Swee Hock School of Public Health, National University of Singapore, Singapore.
36
Department of Health Science, Shiga University of Medical Science, Shiga, Japan.
37
Cardiovascular Epidemiology, Kyoto Women's University, Kyoto, Japan.
38
Bioinformatics Section, Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Showa-ku, Nagoya 466-8560, Japan.
39
Department of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan.
40
Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA.
41
Eulji University, Seongnam City, Gyeonggi-do, Korea.
42
Department of Chemotherapy, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China.
43
Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Shiga, Japan.
44
Department of Genome Science, Aichi-Gakuin University, School of Dentistry, Chikusa-ku, Nagoya, 464-8651, Japan.
45
Institute of Urology and Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
46
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
47
Duke-National University of Singapore Graduate Medical School, Singapore.

Abstract

Sixty genetic loci associated with abdominal obesity, measured by waist circumference (WC) and waist-hip ratio (WHR), have been previously identified, primarily from studies conducted in European-ancestry populations. We conducted a meta-analysis of associations of abdominal obesity with approximately 2.5 million single nucleotide polymorphisms (SNPs) among 53,052 (for WC) and 48,312 (for WHR) individuals of Asian descent, and replicated 33 selected SNPs among 3,762 to 17,110 additional individuals. We identified four novel loci near the EFEMP1, ADAMTSL3 , CNPY2, and GNAS genes that were associated with WC after adjustment for body mass index (BMI); two loci near the NID2 and HLA-DRB5 genes associated with WHR after adjustment for BMI, and three loci near the CEP120, TSC22D2, and SLC22A2 genes associated with WC without adjustment for BMI. Functional enrichment analyses revealed enrichment of corticotropin-releasing hormone signaling, GNRH signaling, and/or CDK5 signaling pathways for those newly-identified loci. Our study provides additional insight on genetic contribution to abdominal obesity.

PMID:
26785701
PMCID:
PMC4726286
DOI:
10.1038/srep17958
[Indexed for MEDLINE]
Free PMC Article

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