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Science. 2015 Dec 4;350(6265):1208-13. doi: 10.1126/science.aac4854.

NAD⁺ in aging, metabolism, and neurodegeneration.

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Gladstone Institutes, Department of Medicine, University of California, San Francisco, San Francisco, CA 94158, USA.


Nicotinamide adenine dinucleotide (NAD(+)) is a coenzyme found in all living cells. It serves both as a critical coenzyme for enzymes that fuel reduction-oxidation reactions, carrying electrons from one reaction to another, and as a cosubstrate for other enzymes such as the sirtuins and poly(adenosine diphosphate-ribose) polymerases. Cellular NAD(+) concentrations change during aging, and modulation of NAD(+) usage or production can prolong both health span and life span. Here we review factors that regulate NAD(+) and discuss how supplementation with NAD(+) precursors may represent a new therapeutic opportunity for aging and its associated disorders, particularly neurodegenerative diseases.

[Indexed for MEDLINE]

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