Send to

Choose Destination
Inflammation. 2016 Apr;39(2):752-8. doi: 10.1007/s10753-015-0302-2.

Protective Effects of Apigenin Against Paraquat-Induced Acute Lung Injury in Mice.

Author information

Department of Pharmacy, Yuhuangding Hospital Affiliated to Qingdao University, Yantai, 264000, China.
Department of Radiology, Linyi People's Hospital, Linyi, 276000, China.
Department of Emergency, Haiyang People's Hospital, No. 73 Haiyang Road, Haiyang, 265100, China.


This study aimed to investigate the protective effects of apigenin against paraquat (PQ)-induced acute lung injury (ALI) in mice. Male Kunming mice were randomly divided into five groups: group 1 (control), group 2 (PQ), group 3 (PQ + apigenin 25 mg/kg), group 4 (PQ + apigenin 50 mg/kg), and group 5 (PQ + apigenin 100 mg/kg). The PQ + apigenin group received apigenin by gavage daily for consecutive 7 days, respectively, while the mice in control and PQ groups were given an equivalent volume of saline. We detected the lung wet/dry weight ratios and the histopathology of the lung. The levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), malondialdehyde (MDA), myeloperoxidase (MPO), superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px) were determined using enzyme-linked immunosorbent assay (ELISA) kits. The activity of nuclear factor (NF)-κB was also determined. The results indicated that apigenin administration decreased biochemical parameters of inflammation and oxidative stress, and improved oxygenation and lung edema in a dose-dependent manner. These protective effects of apigenin were associated with inhibition of NF-κB. In conclusion, apigenin reduces PQ-induced ALI by inhibition of inflammation and oxidative stress.


acute lung injury; apigenin; inflammation; oxidative stress; paraquat

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center