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Mol Psychiatry. 2016 Oct;21(10):1460-6. doi: 10.1038/mp.2015.209. Epub 2016 Jan 19.

Abnormal asymmetries in subcortical brain volume in schizophrenia.

Author information

1
Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
2
Division of Cerebral Integration, National Institute for Physiological Sciences, Aichi, Japan.
3
Division of Ultrahigh Field MRI, Institute for Biomedical Sciences, Iwate Medical University, Iwate, Japan.
4
Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan.
5
Department of Radiology, Osaka University Graduate School of Medicine, Osaka, Japan.
6
Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan.
7
Department of Neuropsychiatry, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
8
Imaging Genetics Center, University of Southern California, Marina del Rey, CA, USA.
9
Department of Psychiatry and Human Behavior, University of California, Irvine, CA, USA.
10
Graduate School of Human Sciences, Osaka University, Osaka, Japan.
11
Department of Psychiatry, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
12
Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
13
Department of Psychiatry, Hokkaido University Graduate School of Medicine, Hokkaido, Japan.
14
Office for Mental Health Support, Division for Counseling and Support, The University of Tokyo, Tokyo, Japan.
15
Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan.
16
Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.
17
Department of Psychiatry, Nagoya University Graduate School of Medicine, Aichi, Japan.
18
Department of Neuropsychiatry, Kanazawa Medical University, Ishikawa, Japan.
19
Department of Psychiatry, University of Occupational and Environmental Health, Fukuoka, Japan.
20
Department of Psychology, Georgia State University, Atlanta, GA, USA.
21
Department of Neuroscience, Georgia State University, Atlanta, GA, USA.
22
Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Osaka, Japan.

Abstract

Subcortical structures, which include the basal ganglia and parts of the limbic system, have key roles in learning, motor control and emotion, but also contribute to higher-order executive functions. Prior studies have reported volumetric alterations in subcortical regions in schizophrenia. Reported results have sometimes been heterogeneous, and few large-scale investigations have been conducted. Moreover, few large-scale studies have assessed asymmetries of subcortical volumes in schizophrenia. Here, as a work completely independent of a study performed by the ENIGMA consortium, we conducted a large-scale multisite study of subcortical volumetric differences between patients with schizophrenia and controls. We also explored the laterality of subcortical regions to identify characteristic similarities and differences between them. T1-weighted images from 1680 healthy individuals and 884 patients with schizophrenia, obtained with 15 imaging protocols at 11 sites, were processed with FreeSurfer. Group differences were calculated for each protocol and meta-analyzed. Compared with controls, patients with schizophrenia demonstrated smaller bilateral hippocampus, amygdala, thalamus and accumbens volumes as well as intracranial volume, but larger bilateral caudate, putamen, pallidum and lateral ventricle volumes. We replicated the rank order of effect sizes for subcortical volumetric changes in schizophrenia reported by the ENIGMA consortium. Further, we revealed leftward asymmetry for thalamus, lateral ventricle, caudate and putamen volumes, and rightward asymmetry for amygdala and hippocampal volumes in both controls and patients with schizophrenia. Also, we demonstrated a schizophrenia-specific leftward asymmetry for pallidum volume. These findings suggest the possibility of aberrant laterality in neural pathways and connectivity patterns related to the pallidum in schizophrenia.

PMID:
26782053
PMCID:
PMC5030462
DOI:
10.1038/mp.2015.209
[Indexed for MEDLINE]
Free PMC Article

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