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Nat Rev Immunol. 2016 Feb;16(2):102-11. doi: 10.1038/nri.2015.10. Epub 2016 Jan 19.

The multifaceted role of CD4(+) T cells in CD8(+) T cell memory.

Author information

1
Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
2
Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California 94143, USA.
3
Department of Internal Medicine (Rheumatology), Yale University School of Medicine, New Haven, Connecticut 06520, USA.
4
Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, Maryland 2081, USA.

Abstract

Following infection, T cells differentiate into a heterogeneous population of effector T cells that can mediate pathogen clearance. A subset of these effector T cells possesses the ability to survive long term and mature into memory T cells that can provide long-term immunity. Understanding the signals that regulate the development of memory T cells is crucial to efforts to design vaccines capable of eliciting T cell-based immunity. CD4(+) T cells are essential in the formation of protective memory CD8(+) T cells following infection or immunization. However, until recently, the mechanisms by which CD4(+) T cells act to support memory CD8(+) T cell development following infection were unclear. Here, we discuss recent studies that provide insight into the multifaceted role of CD4(+) T cells in the regulation of memory CD8(+) T cell differentiation.

PMID:
26781939
PMCID:
PMC4860014
DOI:
10.1038/nri.2015.10
[Indexed for MEDLINE]
Free PMC Article

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