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Elife. 2016 Jan 19;5:e10509. doi: 10.7554/eLife.10509.

The cerebellum linearly encodes whisker position during voluntary movement.

Author information

1
Department of Bioengineering, Imperial College London, , United Kingdom.
2
Graduate School for Integrative Sciences and Engineering, National University of Singapore, , Singapore.
3
Imperial-NUS Joint PhD program, .
4
Lee Kong Chian School of Medicine, Nanyang Technological University, , Singapore.
5
Institute of Molecular and Cell Biology, , Singapore.

Abstract

Active whisking is an important model sensorimotor behavior, but the function of the cerebellum in the rodent whisker system is unknown. We have made patch clamp recordings from Purkinje cells in vivo to identify whether cerebellar output encodes kinematic features of whisking including the phase and set point. We show that Purkinje cell spiking activity changes strongly during whisking bouts. On average, the changes in simple spike rate coincide with or slightly precede movement, indicating that the synaptic drive responsible for these changes is predominantly of efferent (motor) rather than re-afferent (sensory) origin. Remarkably, on-going changes in simple spike rate provide an accurate linear read-out of whisker set point. Thus, despite receiving several hundred thousand discrete synaptic inputs across a non-linear dendritic tree, Purkinje cells integrate parallel fiber input to generate precise information about whisking kinematics through linear changes in firing rate.

KEYWORDS:

Crus I; Purkinje cell; mouse; neuroscience; simple spike; vibrissa

PMID:
26780828
PMCID:
PMC4737656
DOI:
10.7554/eLife.10509
[Indexed for MEDLINE]
Free PMC Article

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