(A) R2 values from 819 cancers of 14 different types supported neutral evolution in a large proportion of cases (259/819, 31.6% of R2≥0.98) and across different cancer types, particularly in stomach (validating the WGS analysis), lung, bladder, cervical and colon. On the contrary, renal, melanoma, pancreatic, thyroid, and glioblastoma were characterized by non-neutral evolution. The other types displayed a mixed dynamics. (B) The highest mutation rates were found in lung cancer. Lower rates were found in thyroid, low grade glioma and prostate.