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Prog Biophys Mol Biol. 2016 Jan;120(1-3):199-209. doi: 10.1016/j.pbiomolbio.2015.12.015. Epub 2016 Jan 11.

The nervous heart.

Author information

1
Department of Pharmacology, University of California Davis, 451 Health Sciences Drive, Davis, CA 95616, USA. Electronic address: cripplinger@ucdavis.edu.
2
Molecular Pharmacology and Physiology, University of South Florida, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA. Electronic address: snoujaim@health.usf.edu.
3
Klinik für Innere Medizin III, Universitätsklinikum des Saarlandes, 66421 Homburg, Saar, Germany. Electronic address: Dominik.Linz@uks.eu.

Abstract

Many cardiac electrophysiological abnormalities are accompanied by autonomic nervous system dysfunction. Here, we review mechanisms by which the cardiac nervous system controls normal and abnormal excitability and may contribute to atrial and ventricular tachyarrhythmias. Moreover, we explore the potential antiarrhythmic and/or arrhythmogenic effects of modulating the autonomic nervous system by several strategies, including ganglionated plexi ablation, vagal and spinal cord stimulations, and renal sympathetic denervation as therapies for atrial and ventricular arrhythmias.

KEYWORDS:

Atrial fibrillation; Autonomic control; Cardiac nerves; Ventricular tachycardia/fibrillation

PMID:
26780507
PMCID:
PMC4808395
DOI:
10.1016/j.pbiomolbio.2015.12.015
[Indexed for MEDLINE]
Free PMC Article

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