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Int J Vitam Nutr Res. 2015;85(1-2):39-49. doi: 10.1024/0300-9831/a000222.

Positive Association of Vitamin E Supplementation with Hemoglobin Levels in Mildly Anemic Healthy Pakistani Adults.

Author information

1
1 Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan.
2
2 Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan.
3
3 Department of Pathology and Microbiology, Aga Khan University, Karachi, Pakistan.

Abstract

BACKGROUND:

Hemoglobin levels slightly below the lower limit of normal are common in adults in the general population in developing countries. A few human studies have suggested the use of antioxidant vitamins in the correction of mild anemia. The objective of the present study was to investigate the association of vitamin E supplementation in mildly anemic healthy adults with post-supplemental blood hemoglobin levels in the general population of Karachi, Pakistan.

METHOD:

In a single-blinded and placebo-controlled randomized trial, 124 mildly anemic subjects from the General Practitioners' Clinics and personnel of the Aga Khan University were randomized into intervention (n = 82) and control (n = 42) group. In the intervention group, each subject was given vitamin E (400 mg) everyday for a period of three months, while control group subjects received a placebo. Eighty six subjects completed the trial. Fasting venous blood was collected at baseline and after three months of supplementation. Hemoglobin levels and serum/plasma concentrations of vitamin E, vitamin B12, folate, ferritin, serum transferrin receptor (sTfR), glucose, total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, creatinine, total-antioxidant-status and erythropoietin were measured and analyzed using repeated measures ANOVA and multiple linear regression.

RESULTS:

The adjusted regression coefficients (β) and standard error [SE(β)] of the significant predictors of post-supplemental hemoglobin levels were serum concentration of vitamin E (0.983[0.095]), gender (- 0.656[0.244]), sTfR (- 0.06[0.02]) and baseline hemoglobin levels (0.768[0.077]).

CONCLUSION:

The study showed a positive association between vitamin E supplementation and enhanced hemoglobin levels in mildly anemic adults.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT02181348.

KEYWORDS:

Pakistani population; anemia; haemoglobin; randomized trial; vitamin E supplementation

PMID:
26780276
DOI:
10.1024/0300-9831/a000222
[Indexed for MEDLINE]

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