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J Control Release. 2016 Jun 10;231:68-76. doi: 10.1016/j.jconrel.2016.01.006. Epub 2016 Jan 9.

Poly-paclitaxel/cyclodextrin-SPION nano-assembly for magnetically guided drug delivery system.

Author information

1
Department of Chemistry Polymer Research Institute, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Republic of Korea.
2
Center for Self-assembly and Complexity, Institute for Basic Science (IBS), Pohang 790-784, Republic of Korea.
3
School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Republic of Korea.
4
Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 136-791 and KU-KIST School, Korea University, Seoul 02841, Republic of Korea.
5
Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu 700-421, Republic of Korea.
6
Bioengineering Department, University of Washington, Seattle, Washington 98195, USA.
7
Department of Chemistry Polymer Research Institute, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Republic of Korea; Center for Self-assembly and Complexity, Institute for Basic Science (IBS), Pohang 790-784, Republic of Korea; School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology (POSTECH), Pohang 790-784, Republic of Korea. Electronic address: wjkim@postech.ac.kr.

Abstract

This work demonstrates the development of magnetically guided drug delivery systems and its potential on efficient anticancer therapy. The magnetically guided drug delivery system was successfully developed by utilizing superparamagnetic iron oxide nanoparticle, β-cyclodextrin, and polymerized paclitaxel. Multivalent host-guest interactions between β-cyclodextrin-conjugated superparamagnetic iron oxide nanoparticle and polymerized paclitaxel allowed to load the paclitaxel and the nanoparticle into the nano-assembly. Clusterized superparamagnetic iron oxide nanoparticles in the nano-assembly permitted the rapid and efficient targeted drug delivery. Compared to the control groups, the developed nano-assembly showed the enhanced anticancer effects in vivo as well as in vitro. Consequently, the strategy of the use of superparamagnetic nanoparticles and multivalent host-guest interactions has a promising potential for developing the efficient drug delivery systems.

KEYWORDS:

Cyclodextrin; Magnetic-guided drug delivery; Multivalent host-guest chemistry; Paclitaxel; SPION

PMID:
26780174
DOI:
10.1016/j.jconrel.2016.01.006
[Indexed for MEDLINE]

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