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Magn Reson Med. 2017 Jan;77(1):209-220. doi: 10.1002/mrm.26110. Epub 2016 Jan 17.

High-resolution diffusion-weighted imaging of the breast with multiband 2D radiofrequency pulses and a generalized parallel imaging reconstruction.

Author information

1
Department of Radiology, Stanford University, Stanford, California, USA.
2
Global Applied Science Laboratory, GE Healthcare, Menlo Park, California, USA.
3
Department of Electrical Engineering, Magnetic Resonance Systems Research Laboratory, Stanford University, Stanford, California, USA.

Abstract

PURPOSE:

To develop a technique for high-resolution diffusion-weighted imaging (DWI) and to compare it with standard DWI methods.

METHODS:

Multiple in-plane bands of magnetization were simultaneously excited by identically phase modulating each subpulse of a two-dimensional (2D) RF pulse. Several excitations with the same multiband pattern progressively shifted in the phase-encode direction were used to cover the prescribed field of view (FOV). The phase-encoded FOV was limited to the width of a single band to reduce off-resonance-induced distortion and blurring. Parallel imaging (PI) techniques were used to resolve aliasing from the other bands and to combine the different excitations. Following validation in phantoms and healthy volunteers, a preliminary study in breast cancer patients (N=14) was performed to compare the proposed method to conventional DWI with PI and to reduced-FOV DWI.

RESULTS:

The proposed method gave high-resolution diffusion-weighted images with minimal artifacts at the band intersections. Compared to PI alone, higher phase-encoded FOV-reduction factors and reduced noise amplification were obtained, which translated to higher resolution images than conventional (non-multiband) DWI. The same resolution and image quality achievable over targeted regions using existing reduced-FOV methods was obtained, but the proposed method also enables complete bilateral coverage.

CONCLUSION:

We developed an in-plane multiband technique for high-resolution DWI and compared its performance with other standard DWI methods. Magn Reson Med 77:209-220, 2017. © 2016 Wiley Periodicals, Inc.

KEYWORDS:

2D RF pulse; DWI; breast; multiband; parallel imaging

PMID:
26778549
DOI:
10.1002/mrm.26110
[Indexed for MEDLINE]

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