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Mutat Res. 1989 Oct;216(5):251-7.

Detection of ionizing radiations with the SOS Chromotest, a bacterial short-term test for genotoxic agents.

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  • 1CNRS 040271, INSERM UA163, Institut Pasteur, Paris, France.


The effects of 3 types of ionizing radiation, gamma-rays, neutrons and accelerated alpha-particles, were examined using the SOS Chromotest, a bacterial colorimetric assay for genotoxic agents based on the measurement of the SOS response in Escherichia coli. The SOS Chromotest appeared to be a sensitive and simple assay to detect quantitatively these radiations as well as their biological effects. The range of adsorbed doses for which induction was observed was similar for the 3 types of radiation, the minimum inducing doses being in the order of 2.5-5 Gy. We discuss the possible use of these observations to study the molecular action of radiations and to compare their genotoxic effects with those of chemicals.

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