Format

Send to

Choose Destination
Mol Aspects Med. 2016 Feb-Mar;47-48:76-89. doi: 10.1016/j.mam.2016.01.002. Epub 2016 Jan 14.

O2 sensing, mitochondria and ROS signaling: The fog is lifting.

Author information

1
Department of Pediatrics, Division of Neonatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA.
2
Department of Pediatrics, Division of Neonatology, Northwestern University, Feinberg School of Medicine, Chicago, IL, USA. Electronic address: p-schumacker@northwestern.edu.

Abstract

Mitochondria are responsible for the majority of oxygen consumption in cells, and thus represent a conceptually appealing site for cellular oxygen sensing. Over the past 40 years, a number of mechanisms to explain how mitochondria participate in oxygen sensing have been proposed. However, no consensus has been reached regarding how mitochondria could regulate transcriptional and post-translational responses to hypoxia. Nevertheless, a growing body of data continues to implicate a role for increased reactive oxygen species (ROS) signals from the electron transport chain (ETC) in triggering responses to hypoxia in diverse cell types. The present article reviews our progress in understanding this field and considers recent advances that provide new insight, helping to lift the fog from this complex topic.

KEYWORDS:

Hypoxia; electron transport chain; metabolism; oxidant signaling

PMID:
26776678
PMCID:
PMC4750107
DOI:
10.1016/j.mam.2016.01.002
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center