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Trends Parasitol. 2016 Apr;32(4):309-324. doi: 10.1016/j.pt.2015.12.010. Epub 2016 Jan 8.

The Flagellum Attachment Zone: 'The Cellular Ruler' of Trypanosome Morphology.

Author information

1
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK. Electronic address: jack.sunter@path.ox.ac.uk.
2
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK.

Abstract

A defining feature of Trypanosoma brucei cell shape is the lateral attachment of the flagellum to the cell body, mediated by the flagellum attachment zone (FAZ). The FAZ is a complex cytoskeletal structure that connects the flagellum skeleton through two membranes to the cytoskeleton. The FAZ acts as a 'cellular ruler' of morphology by regulating cell length and organelle position and is therefore critical for both cell division and life cycle differentiations. Here we provide an overview of the advances in our understanding of the composition, assembly, and function of the FAZ.

KEYWORDS:

FAZ; Trypanosoma brucei; cytoskeleton; flagellum; morphology

PMID:
26776656
PMCID:
PMC4827413
DOI:
10.1016/j.pt.2015.12.010
[Indexed for MEDLINE]
Free PMC Article

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