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Trends Parasitol. 2016 Mar;32(3):207-218. doi: 10.1016/j.pt.2015.10.011. Epub 2015 Nov 20.

Exploiting Intimate Relationships: Controlling Mosquito-Transmitted Disease with Wolbachia.

Author information

1
Grupo Mosquitos Vetores: Endossimbiontes e Interação Patógeno Vetor, Centro de Pesquisas René Rachou - Fiocruz, Belo Horizonte, Minas Gerais, Brazil.
2
Grupo Mosquitos Vetores: Endossimbiontes e Interação Patógeno Vetor, Centro de Pesquisas René Rachou - Fiocruz, Belo Horizonte, Minas Gerais, Brazil. Electronic address: luciano@cpqrr.fiocruz.br.

Abstract

Mosquito-transmitted diseases impose a growing burden on human health, and current control strategies have proven insufficient to stem the tide. The bacterium Wolbachia is a novel and promising form of control for mosquito-transmitted disease. It manipulates host biology, restricts infection with dengue and other pathogens, and alters host reproduction to promote rapid spread in the field. In this review, we examine how the intimate and diverse relationships formed between Wolbachia and their mosquito hosts can be exploited for disease control purposes. We consider these relationships in the context of recent developments, including successful field trials with Wolbachia-infected mosquitoes to combat dengue, and new Wolbachia infections in key malaria vectors, which have enhanced the disease control prospects of this unique bacterium.

KEYWORDS:

Aedes aegypti; Wolbachia; dengue; disease control; host-symbiont interactions; malaria

PMID:
26776329
DOI:
10.1016/j.pt.2015.10.011
[Indexed for MEDLINE]

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