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Sci Rep. 2016 Jan 18;6:19399. doi: 10.1038/srep19399.

Anti-nociceptive effect of Faecalibacterium prausnitzii in non-inflammatory IBS-like models.

Author information

1
INRA, Commensal and Probiotics-Host Interactions Laboratory, UMR 1319 Micalis, F-78350 Jouy-en-Josas, France.
2
AgroParisTech, UMR1319 Micalis, F-78350 Jouy-en-Josas, France.
3
Laboratoire Microorganismes: Génome et Environnement, UMR CNRS 6023, 63000 Clermont-Ferrand, France.
4
Université d'Auvergne, 63000, Clermont-Ferrand, France.
5
INSERM 1107 Neuro-Dol, 630000 Clermont-Ferrand, France.
6
Neuro-Gastroenterology and Nutrition Team, TOXALIM, UMR 1331-INRA/INP/UPS, F-31931 Toulouse, France.
7
APHP, Hôpital Saint Antoine - Service de Gastroentérologie et nutrition, F-75012 Paris, France.
8
Sorbonne Universités, UPMC Univ Paris 06, LBM, 27 rue de Chaligny, F-75012 Paris, France.
9
INSERM-ERL 1157 and Inflammation-Immunopathology-Biotherapy Department (DHU i2B), CHU Saint-Antoine 27 rue de Chaligny, F-75012 Paris, France.
10
CNRS, UMR 7203 LBM, F-75005 Paris, France.

Abstract

Visceral pain and intestinal dysbiosis are associated with Irritable Bowel Syndrome (IBS), a common functional gastrointestinal disorder without available efficient therapies. In this study, a decrease of Faecalibacterium prausnitzii presence has been observed in an IBS-like rodent model induced by a neonatal maternal separation (NMS) stress. Moreover, it was investigated whether F. prausnitzii may have an impact on colonic sensitivity. The A2-165 reference strain, but not its supernatant, significantly decreased colonic hypersensitivity induced by either NMS in mice or partial restraint stress in rats. This effect was associated with a reinforcement of intestinal epithelial barrier. Thus, F. prausnitzii exhibits anti-nociceptive properties, indicating its potential to treat abdominal pain in IBS patients.

PMID:
26775847
PMCID:
PMC4726104
DOI:
10.1038/srep19399
[Indexed for MEDLINE]
Free PMC Article

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