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J Chem Neuroanat. 2016 Sep;75(Pt B):94-8. doi: 10.1016/j.jchemneu.2016.01.002. Epub 2016 Jan 8.

The 2100MHz radiofrequency radiation of a 3G-mobile phone and the DNA oxidative damage in brain.

Author information

1
Department of Medical Biochemistry, Başkent University Faculty of Medicine, Ankara, Turkey.
2
Department of Biophysics, Gazi University Faculty of Medicine and Gazi Non-Ionizing Radiation Protection Center, Ankara, Turkey. Electronic address: elcin.ozgur@gmail.com.
3
Department of Biophysics, Gazi University Faculty of Medicine and Gazi Non-Ionizing Radiation Protection Center, Ankara, Turkey.
4
Department of Otorhinolaryngology, Düzce University Faculty of Medicine, Düzce, Turkey.
5
Department of Medical Biochemistry, Gazi University, Faculty of Medicine, Ankara, Turkey.

Abstract

We aimed to evaluate the effect of 2100MHz radiofrequency radiation emitted by a generator, simulating a 3G-mobile phone on the brain of rats during 10 and 40 days of exposure. The female rats were randomly divided into four groups. Group I; exposed to 3G modulated 2100MHz RFR signal for 6h/day, 5 consecutive days/wk for 2 weeks, group II; control 10 days, were kept in an inactive exposure set-up for 6h/day, 5 consecutive days/wk for 2 weeks, group III; exposed to 3G modulated 2100MHz RFR signal for 6h/day, 5 consecutive days/wk for 8 weeks and group IV; control 40 days, were kept in an inactive exposure set-up for 6h/day, 5 consecutive days/wk for 8 weeks. After the genomic DNA content of brain was extracted, oxidative DNA damage (8-hydroxy-2'deoxyguanosine, pg/mL) and malondialdehyde (MDA, nmoL/g tissue) levels were determined. Our main finding was the increased oxidative DNA damage to brain after 10 days of exposure with the decreased oxidative DNA damage following 40 days of exposure compared to their control groups. Besides decreased lipid peroxidation end product, MDA, was observed after 40 days of exposure. The measured decreased quantities of damage during the 40 days of exposure could be the means of adapted and increased DNA repair mechanisms.

KEYWORDS:

2100MHz radiofrequency radiation; Brain; DNA oxidative damage; Lipid peroxidation; Mobile phone radiation

PMID:
26775761
DOI:
10.1016/j.jchemneu.2016.01.002
[Indexed for MEDLINE]

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