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Life Sci. 2016 Feb 1;146:201-13. doi: 10.1016/j.lfs.2016.01.017. Epub 2016 Jan 14.

Ursolic acid (UA): A metabolite with promising therapeutic potential.

Author information

1
Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, Punjab 160012, India.
2
Department of Biotechnology, Maharishi Markandeshwar University, Mullana, Ambala, Haryana 133207, India. Electronic address: hardeep.biotech@gmail.com.
3
Department of Biotechnology, Maharishi Markandeshwar University, Mullana, Ambala, Haryana 133207, India.

Abstract

Plants are known to produce a variety of bioactive metabolites which are being used to cure various life threatening and chronic diseases. The molecular mechanism of action of such bioactive molecules, may open up new avenues for the scientific community to develop or improve novel therapeutic approaches to tackle dreadful diseases such as cancer and cardiovascular and neurodegenerative disorders. Ursolic acid (UA) is one among the categories of such plant-based therapeutic metabolites having multiple intracellular and extracellular targets that play role in apoptosis, metastasis, angiogenesis and inflammatory processes. Moreover, the synthetic derivatives of UA have also been seen to be involved in a range of pharmacological applications, which are associated with prevention of diseases. Evidences suggest that UA could be used as a potential candidate to develop a comprehensive competent strategy towards the treatment and prevention of health disorders. The review article herein describes the possible therapeutic effects of UA along with putative mechanism of action.

KEYWORDS:

Anti-inflammatory; Anti-metastasis; Anti-oxidant; Apoptosis; Derivatives; Ursolic acid

PMID:
26775565
DOI:
10.1016/j.lfs.2016.01.017
[Indexed for MEDLINE]

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